Jennifer E. Fishovitz

Faculty Profiles

Jennifer Fishovitz

Jennifer E. Fishovitz

Assistant Professor
Chemistry
Chemistry Physics
574.284.4482

Education 

PhD, Case Western Reserve University
BS, Gannon University
 

Research Interests 

  • Enzyme mechanism
  • Enzyme kinetics
  • Inhibitor design
  • Protein characterization

Courses Recently Taught 

  • CHEM 324: Biochemistry
  • CHEM 485: Research
  • CHEM 497: Independent study

Creative and Scholarly Work 

  • Fishovitz, J., Li, M., Frase, H., Hudak, J., Craig, S., Ko, K., Berdis, A. J., Suzuki, C. K., Lee, I. "Active-site-directed chemical tools for profiling mitochondrial Lon protease." ACS Chem. Biol. 6, no. 8 (2011): 781-788.
  • Knott, K., Fishovitz, J., Thorpe, S. B., Lee, I., Santos, W. L. "N-Terminal peptidic boronic acids selectively inhibit human ClpXP." Org. Biomol. Chem. 8, no. 15 (2010): 3451-3456.
  • Otero, L. H., Rojas-Altuve, A., Llarrull, L. I., Carrasco-López, C., Kumarasiri, M., Lastochkin, E., Fishovitz, J., Dawley, M., Hesek, D., Lee, M., Johnson, J. W., Fisher, J. F., Chang, M., Mobashery, S., Hermoso, J. A. "How allosteric control of Staphylococcus aureus penicillin binding protein 2a enables methicillin resistance and physiological function." Proc. Natl. Acad. Sci. U.S.A. 110, no.42 (2013): 16808-16813.
  • Fishovitz, J., Rojas-Altuve, A., Otero, L. H., Dawley, M., Carrasco-López, C., Chang, M., Hermoso, J. A., Mobashery, S. "Disruption of allosteric response as an unprecedented mechanism of resistance to antibiotics." J. Am. Chem. Soc. 136, no. 28 (2014): 9814-9817.
  • Fishovitz J, Taghizadeh N, Fisher JF, Chang M, Mobashery S. "The Tipper-Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus aureus (MRSA)." J Am Chem Soc. 137, no. 20 (2015):6500-5.