| Date | Location | Result | |
| Nov 02, 2010 | Hope College | Hope College 3, Saint Mary's College 0 (25-15,25-19,25-12) | Box score |
| Oct 30, 2010 | Hope College | Hope College 3, Saint Mary's College 0 (25-13,25-6,25-14) | Box score |
| Oct 29, 2010 | Notre Dame, Ind. | Trine University 3, Saint Mary's College 0 (25-22,25-23,25-21) | Box score |
| Oct 27, 2010 | Adrian, Mich. | Saint Mary's College 3, Adrian College 2 (16-25,25-23,20-25,27-25,15-12) | Box score |
| Oct 23, 2010 | Notre Dame, Ind. | Alma College 3, Saint Mary's College 0 (25-8,25-19,25-11) | Box score |
| Oct 22, 2010 | Kalamazoo, Mich. | Kalamazoo College 3, Saint Mary's College 0 (25-14,25-22,25-23) | Box score |
| Oct 19, 2010 | Notre Dame, Ind. | Calvin College 3, Saint Mary's College 0 (25-15,25-17,25-12) | Box score |
| Oct 13, 2010 | Notre Dame, Ind. | Olivet College 3, Saint Mary's College 1 (25-23,25-14,23-25,25-22) | Box score |
| Oct 09, 2010 | Albion, Mich. | Beloit College 3, Saint Mary's College 1 (15-25,25-16,25-13,25-15) | Box score |
| Oct 09, 2010 | Albion, Mich. | Saint Mary's College 3, Albion College 2 (19-25,29-27,25-21,15-25,15-9) | Box score |
| Oct 05, 2010 | Notre Dame, Ind. | Hope College 3, Saint Mary's College 0 (25-10,25-16,25-15) | Box score |
| Sep 29, 2010 | Angola, Ind. | Trine University 3, Saint Mary's College 0 (27-25,25-17,25-16) | Box score |
| Sep 25, 2010 | Notre Dame, Ind | Adrian College 3, Saint Mary's College 1 (22-25,25-17,26-24,25-19) | Box score |
| Sep 24, 2010 | Alma, MI | Alma College 3, Saint Mary's College 0 (25-12,25-7,25-18) | Box score |
| Sep 21, 2010 | Notre Dame, Ind. | Kalamazoo College 3, Saint Mary's College 1 (25-10,16-25,25-12,31-29) | Box score |
| Sep 19, 2010 | North Manchester, IN | Millikin University 3, Saint Mary's College 0 (25-14,25-13,25-15) | Box score |
| Sep 19, 2010 | North Manchester, IN | Purdue North Central 3, Saint Mary's College 1 (25-13,25-22,23-25,25-22) | Box score |
| Sep 18, 2010 | North Manchester, IN | Saint Mary's College 3, Franklin College 1 (26-24,25-10,22-25,25-19) | Box score |
| Sep 15, 2010 | Grand Rapids, MI | Calvin College 3, Saint Mary's College 0 (25-20,25-18,25-18) | Box score |
| Sep 11, 2010 | Olivet, Mich. | Olivet College 3, Saint Mary's College 1 (25-22,25-22,19-25,25-16) | Box score |
| Sep 10, 2010 | Notre Dame, Ind. | Saint Mary's College 3, Albion College 0 (25-13,25-17,25-20) | Box score |
| Sep 04, 2010 | Elmhurst, Ill. | Elmhurst College 3, Saint Mary's College 0 (30-28,25-16,25-18) | Box score |
| Sep 04, 2010 | Elmhurst, Ill. | Saint Mary's College 3, West. New England 0 (25-16,25-23,25-15) | Box score |
| Sep 03, 2010 | Elmhurst, Ill. | Wheaton College 3, Saint Mary's College 2 (25-19,13-25,28-30,25-13,15-8) | Box score |
| Sep 03, 2010 | Elmhurst, Ill. | Univ. of Chicago 3, Saint Mary's College 0 (26-24,25-17,26-24) | Box score |
| Sep 01, 2010 | Mishawaka, Ind. | Bethel College 3, Saint Mary's College 0 (25-17,25-12,25-23) | Box score |