Jennifer Fishovitz

Faculty Profiles

Jennifer Fishovitz

Jennifer Fishovitz

Assistant Professor
Chemistry
Chemistry Physics
162 Science Hall

Phone 

Education 

PhD Chemistry, Case Western Reserve University
BS Chemistry, Gannon University
 

Research Interests 

  • Enzyme mechanisms
  • Enzyme kinetics
  • Inhibitor design
  • Protein characterization

Courses Recently Taught 

  • CHEM 101: Chemistry for the Citizen with Lab
  • CHEM 118L: General, Organic, and Bio-Chemistry Lab
  • CHEM 324: Biochemistry
  • CHEM 361: Advanced Lab I
  • CHEM 424: Advanced Biochemistry
  • CHEM 482: Research

Professional Experience 

Postdoctoral Research Associate, University of Notre Dame, 2011-2015

Creative and Scholarly Work 

  • Speri, E.; Kim, C.; De Benedetti, S.; Qian, Y.; Lastochkin, E.; Fishovitz, J.; Fisher, J.; Mobashery, S. Cinnamonitrile Adjuvants Restore Susceptibility to β-Lactams Against Methicillin-Resistant Staphylococcus aureusACS Med. Chem. Letts201910 (8), 1148-1153.
  • Speri, E.; Fishovitz, J.; Mobashery, S. Structure-Activity Relationship of the Cinnamamide Family of Antibiotic Potentiators for Methicillin-Resistance Staphylococcus aureus (MRSA). Med. Chem. Commun. 2018, 9, 2008-2016.
  • Fishovitz, J.; Sha, Z.; Chilakala, S.; Cheng, I.; Xu, Y.; Lee, I. Utilization of Mechanistic Enzymology to Evaluate the Significance of ADP Binding to Human Lon Protease. Frontiers in Molecular Biosciences 2017, 4, 47.
  • Lee, M.; Hesek, D.; Dik, D. A.; Fishovitz, J.; Lastochkin, E.; Boggess, B.; Fisher, J. F.; Mobashery, S. From Genome to Proteome to Elucidation of Reactions for All Eleven Known Lytic Transglycosylases from Pseudomonas Aeruginosa. Angew. Chem. Int. Ed. 2017, 56 (10), 2735–2739.
  • Dik, D. A.; Domínguez-Gil, T.; Lee, M.; Hesek, D.; Byun, B.; Fishovitz, J.; Boggess, B.; Hellman, L. M.; Fisher, J. F.; Hermoso, J. A.; Mobashery, S. Muropeptide Binding and the X-Ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas Aeruginosa. J. Am. Chem. Soc. 2017, 139 (4), 1448–1451.
  • Boudreau, M. A.; Fishovitz, J.; Llarrull, L. I.; Xiao, Q.; Mobashery, S. Phosphorylation of BlaR1 in Manifestation of Antibiotic Resistance in Methicillin-Resistant Staphylococcus Aureus and Its Abrogation by Small Molecules. ACS infectious diseases 2015, 1 (10), 454–459.
  • Galimand, M.; Fishovitz, J.; Lambert, T.; Barbe, V.; Zajicek, J.; Mobashery, S.; Courvalin, P. AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium Striatum. Antimicrobial Agents and Chemotherapy 2015, 59 (9), 5647–5653.
  • Fishovitz, J.; Taghizadeh, N.; Fisher, J. F.; Chang, M.; Mobashery, S. The Tipper–Strominger Hypothesis and Triggering of Allostery in Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus Aureus (MRSA). J. Am. Chem. Soc. 2015, 137 (20), 6500–6505.
  • Fishovitz, J.; Hermoso, J. A.; Chang, M.; Mobashery, S. Penicillin-Binding Protein 2a of Methicillin-Resistant Staphylococcus Aureus. IUBMB Life 2014, 66 (8), 572–577.
  • Fishovitz, J.; Rojas-Altuve, A.; Otero, L. H.; Dawley, M.; Carrasco-López, C.; Chang, M.; Hermoso, J. A.; Mobashery, S. Disruption of Allosteric Response as an Unprecedented Mechanism of Resistance to Antibiotics. J. Am. Chem. Soc. 2014, 136 (28), 9814–9817.
  • Otero, L. H.; Rojas-Altuve, A.; Llarrull, L. I.; Carrasco-López, C.; Kumarasiri, M.; Lastochkin, E.; Fishovitz, J.; Dawley, M.; Hesek, D.; Lee, M.; Johnson, J. W.; Fisher, J. F.; Chang, M.; Mobashery, S.; Hermoso, J. A. How Allosteric Control of Staphylococcus Aureus Penicillin Binding Protein 2a Enables Methicillin Resistance and Physiological Function. Proceedings of the National Academy of Sciences 2013, 110 (42), 16808–16813.
  • Mikita, N.; Cheng, I.; Fishovitz, J.; Huang, J.; Lee, I. Processive Degradation of Unstructured Protein by Escherichia Coli Lon Occurs via the Slow, Sequential Delivery of Multiple Scissile Sites Followed by Rapid and Synchronized Peptide Bond Cleavage Events. Biochemistry 2013, 52 (33), 5629–5644.
  • Cheng, I.; Mikita, N.; Fishovitz, J.; Frase, H.; Wintrode, P.; Lee, I. Identification of a Region in the N-Terminus of Escherichia Coli Lon That Affects ATPase, Substrate Translocation and Proteolytic Activity. Journal of Molecular Biology 2012, 418 (3–4), 208–225.
  • Kumarasiri, M.; Llarrull, L. I.; Borbulevych, O.; Fishovitz, J.; Lastochkin, E.; Baker, B. M.; Mobashery, S. An Amino Acid Position at Crossroads of Evolution of Protein Function: ANTIBIOTIC SENSOR DOMAIN OF BlaR1 PROTEIN FROM STAPHYLOCOCCUS AUREUS VERSUS CLASS D β-LACTAMASES. Journal of Biological Chemistry 2012, 287 (11), 8232–8241.
  • Fishovitz, J.; Li, M.; Frase, H.; Hudak, J.; Craig, S.; Ko, K.; Berdis, A. J.; Suzuki, C. K.; Lee, I. Active-Site-Directed Chemical Tools for Profiling Mitochondrial Lon Protease. ACS Chem. Biol. 2011, 6 (8), 781–788.
  • Thomas, J.; Fishovitz, J.; Lee, I. Utilization of Positional Isotope Exchange Experiments to Evaluate Reversibility of ATP Hydrolysis Catalyzed by Escherichia Coli Lon proteaseThis Paper Is One of a Selection of Papers Published in This Special Issue Entitled 8th International Conference on AAA Proteins and Has Undergone the Journal’s Usual Peer Review Process. Biochem. Cell Biol. 2010, 88 (1), 119–128.
  • Knott, K.; Fishovitz, J.; Thorpe, S. B.; Lee, I.; Santos, W. L. N-Terminal Peptidic Boronic Acids Selectively Inhibit Human ClpXP. Org. Biomol. Chem. 2010, 8 (15), 3451–3456.
  • Patterson-Ward, J.; Tedesco, J.; Hudak, J.; Fishovitz, J.; Becker, J.; Frase, H.; McNamara, K.; Lee, I. Utilization of Synthetic Peptides to Evaluate the Importance of Substrate Interaction at the Proteolytic Site of Escherichia Coli Lon Protease. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics 2009, 1794 (9), 1355–1363.

Professional Memberships 

American Chemical Society

American Society for Biochemistry and Molecular Biology

Council for Undergraduate Research

Sigma Xi: The Scientific Research Honors Society